Molecular Hydrogen and its Potential Application in Brain Disorders

Mental health issues are prevalent in the United States. Millions of Americans suffer from mental illnesses. Furthermore, these mental illnesses cost America around $193.2 million each year. Also, brain disorders like bipolar disorder and schizophrenia affect individuals in a number of ways that make everyday functioning difficult.

Aside from traditional medicine, molecular hydrogen may be able to offer relief to people suffering from these brain disorders. An overview published in Medical Gas Research talks about the benefits hydrogen gas can have on bipolar disorder and schizophrenia thanks to its ability to combat oxidative stress and mitochondrial dysfunction.

What is Oxidation Stress?

When there are too many free radicals in the body, oxidation stress occurs. Free radicals are unstable molecules with unpaired valence electrons. As these free radicals interact with other cells, cell damage and death can occur.

Moreover, brain disorders like bipolar disorder and schizophrenia cause oxidation stress.

Bipolar Disorder and Oxidative Stress

Bipolar disorder is a mood disorder that includes manic and depressive episodes.

According to the overview, several other issues can cooccur with bipolar disorder, including:

  • Diabetes
  • Heart disease
  • Obesity

Bipolar Disorder and Mitochondrial Dysfunction

The research study offers several pieces of evidence that show people with bipolar disorder have a higher rate of mitochondrial dysfunction than healthy individuals.

Schizophrenia and Oxidative Stress

First of all, schizophrenia is not as common as some other brain disorders. However, it is a serious illness that can be quite devastating. People with schizophrenia can lose touch with reality, experience hallucinations, and delusions.

The overview cites evidence that antioxidant defense is impaired in those with schizophrenia. As a result, oxidative stress occurs.

Schizophrenia and Mitochondrial Dysfunction

Cases of mitochondrial dysfunction have frequently been reported in those with schizophrenia.

Benefits of Molecular Hydrogen

The many findings in this overview showed that the use of molecular hydrogen caused a decrease in oxidative stress as well as mitochondrial dysfunction. Several studies on a variety of issues that can appear in both bipolar disorder and schizophrenia were cited.

Also, the studies showed that molecular hydrogen decreases symptoms of several sicknesses. Thus, molecular hydrogen (H2) is a powerful antioxidant.

Why is Molecular Hydrogen Beneficial?

There are three main reasons that molecular hydrogen is so beneficial:

  • Its ability to enter cells allows molecular hydrogen to benefit the human body
  • Molecular hydrogen causes a response from several protectors within the body
  • This antioxidant benefits cell signaling, metabolism and gene expression


Along with traditional medical treatments, molecular hydrogen has great potential as a therapy for people with brain disorders like bipolar disorder and schizophrenia.

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